In:
Digestive Endoscopy, Wiley, Vol. 26, No. 1 ( 2014-01), p. 69-76
Abstract:
The relationship between the thickness of subepithelial collagen bands ( CB ) and the development of linear ulcerations ( LU ) in collagenous colitis ( CC ) remains unclear. The aim of the present study was to compare the clinical and pathological features, including the thickness of CB , in CC patients with and without LU . Patients and Methods Twenty‐five patients with CC diagnosed by pathological examination of biopsy specimens were analyzed. Eleven patients with LU ( LU group) and 14 patients without LU (non‐ LU group) were compared. Results Ten patients in the LU group and seven in the non‐ LU group were taking lansoprazole ( P = 0.038). Seven patients in the LU group and one in the non‐ LU group were taking non‐steroidal anti‐inflammatory drugs ( NSAIDs ) ( P = 0.004). All LU were locatedin the transverse or left colon. Patients in the LU group were older than those in the non‐ LU group ( P = 0.015). CB were significantly thicker in the LU group than in the non‐ LU group (mean ± SD , 40 ± 21 μm vs 20 ± 11 μm, P = 0.004). Multivariate analysis showed that NSAID s use (odds ratio, 19.236; 95% confidence interval, 1.341–275.869) and CB thickness (odds ratio, 0.893; 95% confidence interval, 0.804–0.999) were independently associated with the development of LU . Conclusion Use of lansoprazole and NSAID s , thick CB , and advanced age are associated with the development of LU in CC patients.
Type of Medium:
Online Resource
ISSN:
0915-5635
,
1443-1661
DOI:
10.1111/den.2014.26.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2020071-7