In:
Diabetes, Obesity and Metabolism, Wiley
Kurzfassung:
To assess the likelihood of dementia in individuals with type 2 diabetes (T2D), distinguishing between those with and without microvascular diseases. Methods Leveraging the National Health Insurance Research Database in Taiwan, we identified individuals newly diagnosed with T2D from 1 January 2009 through 31 December 2014. Multivariable Cox proportional hazard models were used to compare the risk of outcomes. Results Individuals with microvascular disease had a significantly higher risk of all‐cause dementia (adjusted hazard ratio [95% confidence interval] 1.13 [1.09, 1.17] ) compared with matched individuals without microvascular disease. In addition, individuals with diabetic kidney disease and diabetic neuropathy were associated with a significantly increased risk of Alzheimer's disease (1.16 [1.02, 1.32] and 1.14 [1.03, 1.27] ), vascular dementia (1.21 [1.06, 1.38] and 1.14 [1.02, 1.28] ) and other dementia (1.11 [1.04, 1.19] and 1.10 [1.04, 1.16] ), respectively, compared with those without microvascular disease. Conclusions This nationwide cohort study showed that patients with T2D and microvascular disease, particularly diabetic kidney disease and diabetic neuropathy, were associated with a significantly higher risk of Alzheimer's disease, vascular dementia, other dementia and all‐cause dementia than those without microvascular disease.
Materialart:
Online-Ressource
ISSN:
1462-8902
,
1463-1326
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2024
ZDB Id:
2004918-3
