In:
European Journal of Clinical Investigation, Wiley, Vol. 43, No. 11 ( 2013-11), p. 1178-1183
Abstract:
Metabolic syndrome is a common metabolic disorder that is associated with an increased risk of type 2 diabetes and cardiovascular diseases. Disturbances in adrenal steroid hormone production significantly contribute to the development of this disorder. Therefore, it is extremely important to fully understand the mechanisms governing adrenal gland function, both in physiological and pathological conditions. Results Recently, S onic hedgehog has emerged as an important regulator of adrenal development, with a possible role in adult gland homeostasis. Recent work of our group shows that lipoproteins are important regulators of H edgehog signaling; they act as carriers for the spread of Hedgehog proteins, but also contain lipid(s) that inhibit the pathway. Conclusions We propose that lipoproteins may affect S onic hedgehog signaling in the adult adrenal gland at multiple levels. Understanding the interplay between lipoprotein metabolism and adrenal H edgehog signaling may improve our understanding of how adrenal gland disorders contribute to the metabolic syndrome.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2013.43.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2004971-7