In:
European Journal of Clinical Investigation, Wiley, Vol. 46, No. 8 ( 2016-08), p. 721-729
Kurzfassung:
Liver and cholestatic parameters are increased in ST ‐segment elevation myocardial infarction ( STEMI ). The aim of the present study was to evaluate the prognostic value of these parameters to predict in‐hospital major adverse cardiac events ( MACE ) in patients after STEMI . Materials and methods Blood samples of patients with STEMI , who underwent percutaneous coronary intervention ( PCI ) and stent implantation, were retrospectively analysed and correlated with in‐hospital events. Results The study population consisted of 847 consecutive patients (62·4 ± 13·43 years; 73·8% male). The total in‐hospital MACE rate was 9·8%, driven by death of any cause (8·4%). The Mann–Whitney U ‐test revealed that liver and cholestatic parameters (alanine transaminase P 〈 0·0001, aspartate transaminase P 〈 0·0001, alkaline phosphatase ( AP ) P 〈 0·0001, gamma‐glutamyl transferase P = 0·0006 and total bilirubin P = 0·0023) were significantly higher in the MACE group. Further logistic regression analyses confirmed the correlation between MACE and all five laboratory markers, even after adjustment for age and heart enzymes. Logistic regression model revealed AP to be the best predictor for worth outcome ( OR 1·0188; 95% CI 1·0118–1·0258; P 〈 0·0001). Conclusion Liver and cholestatic parameters are elevated in patients after STEMI . Increased AP is associated with in‐hospital event rates.
Materialart:
Online-Ressource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2016.46.issue-8
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2004971-7
