In:
European Journal of Clinical Investigation, Wiley, Vol. 53, No. 1 ( 2023-01)
Kurzfassung:
As neonates are susceptible for many diseases, establishing noninvasive diagnostic methods is desirable. We hypothesized that volatile organic compounds (VOCs) could be successfully measured in diaper samples. Methods We performed a feasibility study to investigate whether ambient air‐independent headspace measurements of the VOC profiles of diapers from premature infants can be conducted using ion mobility spectrometer coupled with multi‐capillary columns (B & S Analytik GmbH). Results We analysed 39 diapers filled with stool ( n = 10) or urine ( n = 20) respectively, using empty diapers as a control ( n = 9). A total of 158 different VOCs were identified, and we classified the content of the diapers (urine or stool) according to their VOC profiles with a significance level of p 〈 0.05. Conclusions We have developed a novel method to study headspace VOC profiles of biosamples using ion mobility spectrometry coupled with multi‐capillary columns. Using this method, we have characterized the VOC profiles of stool and urine of preterm neonates. Future studies are warranted to characterize specific VOC profiles in infections and other diseases of the preterm neonate, thus establishing quick and noninvasive diagnostics in the routine care of the highly vulnerable preterm and term neonates.
Materialart:
Online-Ressource
ISSN:
0014-2972
,
1365-2362
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2023
ZDB Id:
2004971-7
