In:
European Journal of Haematology, Wiley, Vol. 99, No. 2 ( 2017-08), p. 133-140
Abstract:
Aim of this retrospective study was to analyze the dynamics of BKP yV reactivation in allogeneic hematopoietic stem cell transplant recipients in order to identify patients with higher risk to develop BKP yV‐associated hemorrhagic cystitis ( BKP yV‐associated HC ). Methods The study included 58 allo‐ HSCT recipients from the University Hospital of Cologne detected BKP yV positive by real‐time PCR between 2009 and 2015. For correlative analysis, the first detected BKP yV‐ DNA load in urine and in plasma as well as the onset and severity of HC following the first day of conditioning regimen was considered. Phylogenetic analysis of BKP yV isolates was performed. Results In 25 of 58 patients, BKP yV‐ DNA was detected in urine only (group U), whereas 33 patients developed additional viremia (group P). A chronologic sequence viruria‐viremia‐ HC was identified. Viral load of 〉 10 6 copies/ mL at first viruria and evidence of viremia after 45 days from the start of conditioning represented risk factors for the onset of HC . Molecular characterization revealed a non‐stereotypic distribution of viral subtypes across groups U and P. Conclusions Monitoring of BKP yV‐ DNA by real‐time PCR after initiation of conditioning, regularly performed in clinical practice, can be a crucial tool for the early identification of patients with higher risk of BKP yV‐associated HC .
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2017.99.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027114-1