In:
European Journal of Haematology, Wiley, Vol. 100, No. 2 ( 2018-02), p. 171-181
Abstract:
To explore the possible risk factors for the occurrence and mortality of thrombotic microangiopathy ( TMA ) with concomitant acute graft‐vs‐host disease ( aGVHD ) and to investigate outcomes and treatments of this disorder after allo‐ HSCT . Methods Fifty cases diagnosed with TMA with concomitant aGVHD and 150 controls were identified from a cohort composed of 3992 patients who underwent allo‐ HSCT from 2008 to 2016. Results Grade III ‐ IV aGVHD ( P = .000), acute kidney injury ( AKI ) ( P = .033), and hypertension ( P = .028) were significant independent risk factors associated with the occurrence of TMA with concomitant aGVHD . A haptoglobin level below normal ( P = .013), a maximum volume of diarrhea 〉 2500 mL/d ( P = .015), and bloody diarrhea ( P = .049) were significant markers for death in both univariate and multivariate analyses. Patients diagnosed with TMA with concomitant aGVHD had a lower overall survival (OS), a higher non‐relapse mortality ( NRM ), but a lower risk of relapse. Conclusions Thrombotic microangiopathy with concomitant aGVHD is a significant complication after allo‐ HSCT , with a worse outcome, including significantly lower OS and higher NRM . There are specific risk factors associated with occurrence and mortality of this complication.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2018.100.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2027114-1