In:
European Journal of Haematology, Wiley, Vol. 110, No. 4 ( 2023-04), p. 396-406
Abstract:
The immune dysregulation during SARS‐CoV‐2 has the potential to worsen immune homeostasis after recovery. Patients with hematological malignancies with COVID‐19 have changes both in the innate and adaptive immune responses. Little is known about the severity of immune dysfunction following recovery from COVID‐19 in hematological patients. Methods Here, we performed a comprehensive analysis of the lymphocyte subsets in peripheral blood mononuclear cells by FACS Canto II in 55 patients, including 42 with hematological malignancies 4–6 weeks after COVID‐19. Results Hematological COVID‐19 convalescents had deep reduction in CD3+ T cells, including helper T cells (CD3 + CD4+), naïve helper T cells (CD3 + CD4 + CD45RA+), and memory CD4+ T cells among with extremely low levels of Treg cells and decreased expression of both TCRα/β and TCRγ/δ. Severe immune dysregulation in hematological convalescents was expressed by increased activation of T lymphocytes, both as elevated levels of activated T cells (CD3 + HLA‐DR+) and activated cytotoxic T cells (CD3 + CD8 + HLA‐DR+). Conclusions Our findings showed a profound impairment of the adaptive immune response in hematological convalescents which might be a result of persistent activation of T cells. Convalescents with lymphoid malignancies showed more pronounced depletion of key T lymphocytes subpopulations in creating an effective adaptive response and immune memory.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2027114-1