In:
Epilepsia, Wiley, Vol. 57, No. 2 ( 2016-02)
Abstract:
We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)‐1α, IL‐6, IL‐10, chemokine (C‐C motif) ligand (CCL)2 and chemokine (C‐X‐C motif) ligand (CXCL)8/IL‐8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow‐up analyses in five patients revealed a significant decrease of IL‐6 levels after immunomodulating treatment. IL‐6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL‐6 correlates with disease activity and immunomodulating treatment efficacy.
Type of Medium:
Online Resource
ISSN:
0013-9580
,
1528-1167
DOI:
10.1111/epi.2016.57.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2002194-X