In:
Epilepsia, Wiley, Vol. 63, No. 4 ( 2022-04), p. 812-823
Kurzfassung:
Postsurgical seizure outcome following laser interstitial thermal therapy (LiTT) for the management of drug‐resistant mesial temporal lobe epilepsy (MTLE) has been limited to 2 years. Furthermore, its impact on presurgical mood and anxiety disorders has not been investigated. The objectives of this study were (1) to identify seizure outcome changes over a period ranging from 18 to 81 months; (2) to investigate the seizure‐free rate in the last follow‐up year; (3) to identify the variables associated with seizure freedom; and (4) to identify the impact of LiTT on presurgical mood and anxiety disorders. Methods Medical records of all patients who underwent LiTT for MTLE from 2013 to 2019 at the University of Miami Comprehensive Epilepsy Center were retrospectively reviewed. Demographic, epilepsy‐related, cognitive, psychiatric, and LiTT‐related data were compared between seizure‐free (Engel Class I) and non‐seizure‐free (Engel Class II + III + IV) patients. Statistical analyses included univariate and multivariate stepwise logistic regression analyses. Results Forty‐eight patients (mean age = 43 ± 14.2 years, range = 21–78) were followed for a mean period of 50 ± 20.7 months (range = 18–81); 29 (60.4%) achieved an Engel Class I outcome, whereas 11 (22.9%) had one to three seizures/year. Seizure‐freedom rate decreased from 77.8% to 50% among patients with 24‐ and 〉 61‐month follow‐up periods, respectively. In the last follow‐up year, 83% of all patients were seizure‐free. Seizure freedom was associated with having mesial temporal sclerosis (MTS), no presurgical focal to bilateral tonic–clonic seizures, and no psychopathology in the last follow‐up year. Presurgical mood and/or anxiety disorder were identified in 30 patients (62.5%) and remitted after LiTT in 19 (62%). Significance LiTT appears to be a safe and effective surgical option for treatment‐resistant MTLE, particularly among patients with MTS. Remission of presurgical mood and anxiety disorders can also result from LiTT.
Materialart:
Online-Ressource
ISSN:
0013-9580
,
1528-1167
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2022
ZDB Id:
2002194-X
