In:
Experimental Dermatology, Wiley, Vol. 23, No. 7 ( 2014-07), p. 521-523
Abstract:
Mesenchymal stem cells ( MSC s) have immunoregulatory and proangiogenic effects and are suggested to be involved in the pathological processes of immune‐related diseases, including psoriasis. Biological characteristics of bone marrow MSC s ( BMSC s) from patients with autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis, but not psoriasis, have been characterized. We compared the gene expression profile and biological characteristics of BMSC s from patients with psoriasis and healthy controls. Although the phenotype, differentiation potential and ability to support CD 34 + cell proliferation were similar to those of normal BMSC s, psoriatic BMSC s showed aberrant proliferative activity, increased apoptosis rate and a characteristic gene expression profile. These aberrations may develop after the abnormal immune response in psoriasis and result in BMSC dysfunction. The functionally deficient BMSC s may then fail to suppress overactive immune cells, thereby contributing to the pathogenesis of psoriasis.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2014.23.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2026228-0