In:
Experimental Dermatology, Wiley, Vol. 27, No. 4 ( 2018-04), p. 393-395
Kurzfassung:
Aero‐allergens, such as house dust mite ( HDM ), have been suggested to play a role in the initiation of atopic dermatitis ( AD )‐related skin inflammation. Here, we analysed the proliferation and the cytokine expression of blood‐derived T cells from AD and healthy individuals upon HDM ‐allergen stimulation. The proliferating cells from healthy individuals and AD patients had a significantly different, distinct cytokine profile: in AD blood, we found increased frequencies of HDM ‐reactive IL ‐31‐producing T cells, as well as a decreased Th1/Th2 and Tc1/Tc2 ratio, suggesting that allergen‐specific T cells in blood of chronic AD patients are subject to pre‐existent Th2‐Tc2 and “Th31‐Tc31” programming.
Materialart:
Online-Ressource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2018.27.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2026228-0
