In:
Experimental Dermatology, Wiley, Vol. 27, No. 11 ( 2018-11), p. 1273-1279
Abstract:
Psoriasis is a chronic autoimmune disease with keratinocyte activation and lymphocyte infiltration in the skin. Our previous study found that 5‐hydroxytryptophan (5( OH )Trp), a tryptophan metabolite, alleviated collagen‐induced arthritis and suppressed cytokine production. In this study, we evaluated the effects of 5( OH )Trp in a mouse model for psoriasiform dermatitis, induced by imiquimod ( IMQ ). We showed that 5( OH )Trp significantly reduced the cumulative scores, epidermal thickness and ki‐67 expression in the skin. In addition, 5( OH )Trp decreased local and systemic inflammation. Moreover, 5( OH )Trp significantly inhibited keratinocyte activation with decrease in IL ‐6 production and p‐Erk1/2 and p‐ STAT 3 expression. 5( OH )Trp also inhibited the differentiation of IFN ‐γ‐ and IL ‐17A‐expressing CD 4 + T cells and related cytokine production ( TNF ‐α, IL ‐6, IL ‐17A and IFN ‐γ) in splenocytes. In conclusion, 5( OH )Trp can inhibit imiquimod‐induced psoriasiform dermatitis in mice and inhibit activation in keratinocytes and splenocytes.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2018.27.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2026228-0