In:
Fundamental & Clinical Pharmacology, Wiley, Vol. 34, No. 3 ( 2020-06), p. 408-411
Abstract:
One of the posttransplantation complications is represented by chronic lung allograft dysfunction, which has two main clinical presentations: bronchiolitis obliterans syndrome and restrictive allograft syndrome. The latter being challenging because of poor prognosis and only symptomatic treatment, and characterized by fibrotic process. A 63‐year‐old man was right lung‐transplanted in 2009 due to idiopathic pulmonary fibrosis. In 2011, bronchiolitis obliterans syndrome was diagnosed evolving to restrictive allograft syndrome in 2016. An off‐label treatment by nintedanib (150 mg twice a day) was introduced. Unfortunately, it was stopped 4 months later because of digestive intolerance, without any clinical improvement. Contrary to a previous case reported, our patient did not have any benefit of nintedanib. Antifibrotic agents' effects such as nintedanib on restrictive allograft syndrome should be assessed in further randomized double‐blind placebo‐controlled studies.
Type of Medium:
Online Resource
ISSN:
0767-3981
,
1472-8206
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2006242-4
SSG:
15,3