In:
Geriatrics & Gerontology International, Wiley, Vol. 15, No. 8 ( 2015-08), p. 1064-1072
Abstract:
Although recent studies suggest that several antihypertensive drugs could reduce the risk of bone fracture, it is still unclear how these drugs act on bone remodeling, especially in elderly women with severe osteoporosis with disuse syndrome. In the present study, we investigated the effects of a calcium channel blocker ( CCB ) and an angiotensin II receptor blocker ( ARB ) on bone metabolism in elderly bedridden women with hypertension and disuse syndrome. Methods Elderly bedridden women (aged 〉 75 years) receiving antihypertensive therapy treated with CCB were recruited in the present study. The participants were divided into two groups – CCB group and ARB group – and followed up to 12 months. Results Markers of bone resorption were markedly increased, suggesting accelerated bone resorption in the participants of the present study. In the follow‐up period, the patients treated with a CCB showed a significant decrease in bone mineral density in a time‐dependent manner, accompanied by a significant increase in bone resorption markers, whereas treatment with olmesartan inhibited bone loss, associated with attenuation of increased bone resorption markers. Bone mineral density of femoral neck in the CCB group was significantly lower than that in the ARB group at 6 months. Conclusion The present study showed inhibitory effects of an ARB on bone resorption in hypertensive patients with accelerated bone resorption, such as elderly bedridden women, and indicated an important role of the renin–angiotensin system in bone metabolism. In elderly hypertensive patients, ARB might be expected to have additional beneficial potential to maintain bone health in bedridden patients. Geriatr Gerontol Int 2015; 15: 1064–1072.
Type of Medium:
Online Resource
ISSN:
1444-1586
,
1447-0594
DOI:
10.1111/ggi.2015.15.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2078308-5
