In:
Hemodialysis International, Wiley, Vol. 19, No. 3 ( 2015-07), p. 452-462
Abstract:
Epicardial adipose tissue ( EAT ) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis ( MHD ) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross‐sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular ( LV ) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance ( HOMA ‐ IR ) and hemodialysis dose by single‐pool urea clearence index ( spKt/V ) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P 〈 0.001), waist circumference (β = 0.572, P 〈 0.001), body fat mass (β = 0.562, P 〈 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = −0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high‐density lipoprotein cholesterol ratio (β = 0.529, P 〈 0.001), 1/ HOMA ‐ IR (β = −0.386, P = 0.006), and spKt/V (β = −0.311, P = 0.028). No association was exhibited with visfatin C , high‐sensitivity C ‐reactive protein, interleukin‐6, and tumor necrosis factor‐alpha (for all, P 〉 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high‐density lipoprotein cholesterol ratio, HOMA ‐ IR , and spKt/V appeared as independent predictors of EAT . EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
Type of Medium:
Online Resource
ISSN:
1492-7535
,
1542-4758
DOI:
10.1111/hdi.2015.19.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2103570-2
