In:
Helicobacter, Wiley, Vol. 22, No. 4 ( 2017-08)
Abstract:
Corpus‐predominant gastritis index ( CGI ) is an early histological marker to identify Helicobacter pylori ‐infected gastric cancer relatives at risk of cancer. This study validated whether CGI is more prevalent in H. pylori ‐infected nonulcer dyspepsia ( NUD ) subjects than in duodenal ulcer ( DU ) controls and whether it is reversible after H. pylori eradication or is correlated with noninvasive biomarkers. Materials and Methods In this longitudinal cohort study, 573 H. pylori ‐infected subjects were enrolled, including 349 NUD and 224 DU . Gastric specimens were provided to assess CGI , spasmolyic polypeptide‐expressing metaplasia ( SPEM ), and Operative Link on Gastric Intestinal Metaplasia assessment ( OLGIM ). Serum pepsinogen I and II levels were assessed using enzyme‐linked immunosorbent assay. CGI subjected were followed up at least 1 year after H. pylori eradication. Results NUD subjects had higher prevalence rates of CGI (47.0% vs 29.9%, P 〈 .001) and OLGIM stages III ‐ IV (24.1% vs 15.2%, P =.01) than controls. CGI was highly prevalent in NUD subjects after the age of 40, which was 10 years earlier than atrophic gastritis and intestinal metaplasia. NUD subjects with CGI had higher risk of SPEM ( OR 2.86, P 〈 .001) and lower serum pepsinogen I/ II ratios ( P 〈 .001) than those without CGI . Serum pepsinogen I/ II ratios 〈 9 could predict CGI modestly ( AUROC 0.69, 95% CI : 0.63‐0.74). CGI was regressed after eradication ( P 〈 .001). Conclusions CGI was more prevalent in H. pylori ‐infected NUD subjects than in controls, was correlated with SPEM , and may serve as a marker earlier than OLGIM to indicate risk of gastric cancer. Moreover, CGI could be regressed after eradication.
Type of Medium:
Online Resource
ISSN:
1083-4389
,
1523-5378
DOI:
10.1111/hel.2017.22.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2020336-6
SSG:
12
