In:
Histopathology, Wiley, Vol. 63, No. 2 ( 2013-08), p. 167-173
Abstract:
The liver and lung are the organs most commonly affected by metastasis in colorectal cancer ( CRC ), and the interaction of chemokines and chemokine receptors ( CKR s) plays an important role in the metastatic process. The aim of this study was to investigate the organ specificity of CKR s in CRC distant metastasis. Methods and results Surgical specimens of primary tumours from 46 patients with metachronous distant metastases were retrieved retrospectively (20 lung metastases; 26 liver metastases). As a control, the records of 29 patients without distant metastases were randomly retrieved from our database, and their specimens were reassessed. The expression rates of CKR s, including CCR 6, CXCR 2, and CXCR 4, were determined by immunohistochemistry, and were compared among the groups. The expression rates of CCR 6 and CXCR 2 were both significantly higher in the metastasis group than in the non‐metastasis group ( P 〈 0.05), but there was no statistical difference between the lung metastasis and liver metastasis subgroups. The expression of CXCR 4 was not significantly different between the metastasis and non‐metastasis groups. Multivariable analysis suggested that preoperative serum carcinoembryonic antigen level, CCR 6 and CXCR 2 were independent factors associated with distant metastasis. Conclusions The expression of CCR 6 and CXCR 2 in CRC could predict metachronous distant metastasis, but they have no organ specificity for metastasis.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2013.63.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2006447-0
