In:
Histopathology, Wiley, Vol. 64, No. 5 ( 2014-04), p. 647-659
Abstract:
Invasive breast carcinoma ( IBC ) with neuroendocrine ( NE ) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence and clinical significance of NE differentiation in patients with IBC . Methods and results We performed immunohistochemistry for NE markers, chromogranin‐ A and synaptophysin on 1428 IBC samples using tissue microarrays and classified cases with NE differentiation into two groups, focal (1–49% tumour cells positive for any NE marker) and diffuse (≥50% tumour cells positive) groups. Fifty‐nine cases (4.1%) showed NE differentiation immunohistochemically, and the majority did not show typical NE morphology. The presence of NE differentiation showed a significant association with positive oestrogen receptor ( P = 0.001) and progesterone receptor ( P = 0.008) status. P atients with NE differentiation showed worse overall survival ( OS ) and disease‐free survival ( DFS ) than those without NE differentiation in both univariate ( P 〈 0.001 for both) and multivariate ( OS , P = 0.004; DFS , P 〈 0.001) analyses. Conclusions IBC with NE differentiation is a distinct subtype of mammary carcinoma with an aggressive clinical outcome.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2014.64.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006447-0
