In:
Histopathology, Wiley, Vol. 65, No. 1 ( 2014-07), p. 9-23
Abstract:
Syringomatous tumour of the nipple and low‐grade adenosquamous carcinoma ( LGA d SC ) of the breast are regarded as distinct entities. To clarify the nature of these two lesions, we compared the expression of different lineage/differentiation markers in 12 syringomatous tumours of the nipple, nine LGA d SC s, and normal breast epithelium. Methods and results Using triple immunofluorescence labelling and quantitative RT ‐ PCR for keratins, p63, and smooth muscle actin, we demonstrated that syringomatous tumour and LGA d SC contain p63+/ K 5/14+ tumour cells, K 10+ squamous cells, and K 8/18+ glandular cells, with intermediary cells being found in both lineages. Identical p63+/ K 5/14+ cells were also found in the normal breast duct epithelium. Conclusions Our data provide evidence that syringomatous tumour of the nipple and LGA d SC are identical or nearly identical lesions. They contain p63+/ K 5/14+ cells as the key cells from which the K 10+ squamous lineage and the K 8/18+ glandular lineage arise. On the basis of our findings in normal breast tissue and associated benign lesions, we suggest that p63+/ K 5/14+ cells of the normal breast duct epithelium or early related cells might play a key role in the neoplastic transformation of both syringomatous tumour and LGA d SC . We propose that the differentiation patterns found in both lesions reflect the early ontogenetic stages of the normal breast epithelium.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2014.65.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006447-0