In:
Internal Medicine Journal, Wiley, Vol. 45, No. 2 ( 2015-02), p. 160-169
Abstract:
Liver cirrhosis is an important cause of morbidity and mortality; however, little is known about its impact in N ew Z ealand. Aims We aim to determine the disease burden, epidemiology and outcomes of cirrhotic patients. Methods This is a retrospective study of cirrhosis patients under secondary public hospital care in a geographically defined region, between the years 2000 and 2011. Cirrhosis complications and mortality was recorded. Poisson log‐linear regression analysis was performed for incidence rate ratio ( IRR ) and C ox regression analysis was used to analyse time‐related events. Results Seven hundred and forty‐six cirrhotic patients were analysed; most were E uropean/Other (39.9%), P acific islanders (21.6%), S outheast A sian/ C hinese (17.8%) and M aori (12.3%). 68.4% were male. The common primary aetiologies for cirrhosis were chronic hepatitis B ( CHB ) cirrhosis (37.3%), alcoholic liver disease ( ALD ) cirrhosis (24.1%), chronic hepatitis C ( CHC ) cirrhosis (22.3%) and non‐alcoholic fatty liver disease ( NAFLD ) cirrhosis (16.4%). The hepatocellular carcinoma ( HCC ) mortality rates were highest in NAFLD and CHB cirrhosis groups (3.0 and 3.1 per 100 patient‐year respectively), compared with ALD and CHC groups (2.2 and 1.4 per 100 patient‐year, all P 〈 0.05 respectively). Patients with ALD and NAFLD cirrhosis had the highest all‐cause and non‐ HCC mortality rate compared with viral hepatitis cirrhosis groups. The IRR for HCC incidence, liver‐related mortality and HCC mortality were 1.087, 1.098 and 1.114, respectively (all P 〈 0.001), suggesting increasing incidence and disease burden over the study period. Conclusion The number of cirrhotic patients in secondary care is increasing steadily. Cirrhosis complications and mortality rates are also rising, particularly the incidence and mortality of HCC .
Type of Medium:
Online Resource
ISSN:
1444-0903
,
1445-5994
DOI:
10.1111/imj.2015.45.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2044081-9
