In:
Influenza and Other Respiratory Viruses, Wiley, Vol. 8, No. 4 ( 2014-07), p. 436-442
Abstract:
Human rhinovirus/enterovirus ( HRV / ENT ) infections are commonly identified in children with acute respiratory infections ( ARI s), but data on their clinical severity remain limited. Objectives We compared the clinical severity of HRV / ENT to respiratory syncytial virus ( RSV ), influenza A / B ( FLU ), and other common respiratory viruses in children. Patients/Methods Retrospective study of children with ARI s and confirmed single positive viral infections on mid‐turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization 〉 5 days, oxygen requirements or death. Results A total of 116 HRV / ENT , 102 RSV , 99 FLU , and 64 other common respiratory viruses were identified. Children with single HRV / ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37·9% versus 13·6%; P 〈 0·001), FLU (37·9% versus 22%; P = 0·018) or any other single viral infection (37·9% versus 22·5%; P = 0·024). In multivariable analysis adjusted for underlying conditions and age, children with HRV / ENT infections had increased odds of hospitalization compared to children with RSV infections ( OR 2·6; 95% CI 1·4, 4·8; P 〈 0·003) or FLU infections ( OR 3·0; 95% CI 1·6, 5·8; 〈 0·001) and increased odds of severe clinical disease among inpatients ( OR 3·0; 95% CI 1·6,5·6; P = 0·001) when compared to those with FLU infections. Conclusions Children with HRV / ENT had a more severe clinical course than those with RSV and FLUA / B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV / ENT infection in children presenting with severe acute respiratory tract infections.
Type of Medium:
Online Resource
ISSN:
1750-2640
,
1750-2659
DOI:
10.1111/irv.2014.8.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2272349-3
