In:
Clinical Endocrinology, Wiley, Vol. 77, No. 3 ( 2012-09), p. 439-445
Abstract:
Insulin resistance is a core feature of polycystic ovary syndrome ( PCOS ). Recently, genome‐wide association studies have reported a number of single‐nucleotide polymorphisms ( SNP s) with reproducible associations and susceptibilities to type 2 diabetes. We examined the potential association between the diabetogenic genes uncovered in the genome‐wide association studies and PCOS in K orean women. Design Case–control study. Patients Women with or without PCOS . Measurements DNA samples from 377 patients with PCOS and 386 age‐matched controls were genotyped. Results None of the 12 SNP s in the six genes ( KCNJ11 , TCF7L2 , SLC30A8 , HHEX , FTO and CDKAL1 ) uncovered in the genome‐wide association studies were associated with PCOS . For further analysis, the patients with PCOS were divided into two or three subgroups according to genotype, and the associations between the genotypes and insulin resistance or insulin secretory capacity were assessed. No SNP s were significantly associated with HOMA ‐ IR , HOMA βcell (%), or 2‐h 75‐g oral glucose tolerance test insulin levels in the patients with PCOS ; there were no significant associations with other serum hormonal and metabolic markers, such as androgen or glucose levels. Conclusions Our results suggest that the six type 2 diabetes–associated genes identified in genome‐wide association studies are not associated with PCOS .
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2012.77.issue-3
DOI:
10.1111/j.1365-2265.2012.04389.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2004597-9
