In:
Scandinavian Journal of Immunology, Wiley, Vol. 8, No. s8 ( 1978-10), p. 371-377
Abstract:
Patients with germ cell tumors, hepatomas and other malignant tumors were studied throughout their courses of surgical, radiological and medical treatments with serial determinations of AFP, CEA, HCG and basic fetoprotein (BFP), which was newly found by M. Ishii. In general, these carcinoembryonic or trophoblastic markers were observed to be well correlated with the fate of the tumor in the body and to be useful in evaluating the effect of treatment or in predicting the prognosis of the patient. Except for a postoperative transient increase in serum BFP and CEA, the levels fell after surgery and rose again with recurrence of the tumor. Although we had some patients with teratocarcinoma, hepatoma or gastric carcinoma, whose serum AFP showed a transient parallelism with their clinical courses, an obvious dissociation in these markers occurred later in their course. Similar dissociations were also observed with these carcinofetal or trophoblastic markers in patients with chemotherapy or radiotherapy for their teratocarcinomas. We conclude that each carcinoembryonic protein is a useful but limited marker for malignancy but should be used clinically in combination with other tumor markers.
Type of Medium:
Online Resource
ISSN:
0300-9475
,
1365-3083
DOI:
10.1111/sji.1978.8.issue-s8
DOI:
10.1111/j.1365-3083.1978.tb03946.x
Language:
English
Publisher:
Wiley
Publication Date:
1978
detail.hit.zdb_id:
2020954-X
