In:
Clinical Transplantation, Wiley, Vol. 20, No. 4 ( 2006-07), p. 496-503
Kurzfassung:
Abstract: We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies 〈 50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)‐matched donors, via either reduced intensity (n = 35) or myeloablative conditioning (n = 70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p = 0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count 〉 0.5 × 10 9 /L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0–21 d) than in the myeloablative group (median: 18 d; range: 11–38 d; p 〈 0.0001). The incidence of grades 2–4 acute graft‐vs.‐host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p = 0.40). The cumulative incidence of day 100 non‐relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p = 0.88). The overall two‐yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p = 0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies.
Materialart:
Online-Ressource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2006.20.issue-4
DOI:
10.1111/j.1399-0012.2006.00512.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2006
ZDB Id:
2739458-X
ZDB Id:
2004801-4