In:
Neuropathology, Wiley, Vol. 18, No. 3 ( 1998-09), p. 284-288
Kurzfassung:
In order to investigate plasma membrane Ca 2+ ‐ATPase (Ca 2+ ‐ATPase) activity in three subsets of microglia/macrophages (microglia in perineuronal regions (perineuronal microglia)), microglia in contact with the parenchymal side of the vascular basal lamina (juxtavascular microglia) and perivascular cells within the basal lamina), we performed an ultracytochemical study using a lead salt technique in rat cerebral cortices. In 60.6% of perineuronal microglia, the cytochemical reaction (CR) for Ca 2+ ‐ATPase on the plasma membrane (PM) in the vicinity of neurons was stronger than the CR on the other side of the PM, and deposits of the reaction product (RP) for Ca 2+ ‐ATPase had accumulated, reflecting the polarity of Ca 2+ ‐ATPase activity. In contrast, in all of juxtavascular microglia and perivascular cells, deposits of the RP were distributed evenly along the PM without polarity. These results suggest that the polarity of the Ca 2+ ‐ATPase activity manifests certain functional interactions between perineuronal microglia and neurons.
Materialart:
Online-Ressource
ISSN:
0919-6544
,
1440-1789
DOI:
10.1111/neu.1998.18.issue-3
DOI:
10.1111/j.1440-1789.1998.tb00116.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1998
ZDB Id:
2008290-3
