In:
Pathology International, Wiley, Vol. 56, No. 2 ( 2006-02), p. 62-70
Abstract:
To clarify possible roles of adhesion molecules including E‐cadherin, β‐ and γ‐catenin, CD44s, CD44v6, CD56, and CD99 in ovarian serous neoplasms, an immunohistochemical study was undertaken for 23 benign, 40 borderline, and 95 malignant ovarian serous neoplasms using tissue microarray (TMA). Significantly reduced expression of E‐cadherin, and overexpression of CD44s, CD56, and CD99 were more frequently observed in adenocarcinomas than in benign and borderline tumors. Expression of CD44v6 and nuclear β‐ and γ‐catenin were detected only in borderline tumors and adenocarcinomas. Reduced expression of E‐cadherin was also correlated with high tumor grade ( P = 0.03), presence of peritoneal seeding ( P = 0.03), and low overall survival rate ( P = 0.02). Overexpression of CD44s was significantly associated with high tumor grade ( P = 0.04), advanced stage ( P = 0.03), and low overall survival rate ( P = 0.02). CD56 was increasingly expressed in the case of advanced stage ( P = 0.005) and peritoneal seeding ( P = 0.001). Nuclear staining for γ‐catenin was correlated with tumor progression ( P = 0.004) and advanced International Federation of Gynecology and Obstetrics (FIGO) stage ( P = 0.02). Only CD44s expression and stage were correlated with overall survival in multivariate study. These results suggest that although E‐cadherin, CD44s, CD56, and nuclear γ‐catenin immunoexpression seem to be useful prognostic markers for serous neoplasm of the ovary, CD44s expression and FIGO stage are independent prognostic factors.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1111/pin.2006.56.issue-2
DOI:
10.1111/j.1440-1827.2006.01925.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2008574-6
