In:
Pathology International, Wiley, Vol. 57, No. 3 ( 2007-03), p. 153-157
Abstract:
Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low‐grade fibromyxoid sarcoma (LGFMS). Lung involvement of HSCT is extremely rare, and only one case has been reported in the English‐language literature. Reported herein is a case of primary pulmonary HSCT that had FUS‐CREB3L2 fusion transcripts, a product of characteristic chromosomal abnormality t(7;16)(q33;p11) of HSCT and LGFMS. The patient was a 50‐year‐old woman who had a large solitary mass in the lung. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription–polymerase chain reaction (RT‐PCR) assay using formalin‐fixed, paraffin‐embedded tissue detected FUS‐CREB3L2 fusion transcripts. Despite its bland morphology, it is known as low‐grade sarcoma and its recognition in the lung would be helpful for accurate diagnosis and proper management of this rare tumor. RT‐PCR for detection of FUS‐CREB3L2 fusion transcripts is a useful method for differential diagnosis of primary pulmonary HSCT.
Type of Medium:
Online Resource
ISSN:
1320-5463
,
1440-1827
DOI:
10.1111/pin.2007.57.issue-3
DOI:
10.1111/j.1440-1827.2006.02073.x
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2008574-6