In:
Psychophysiology, Wiley, Vol. 42, No. 4 ( 2005-07), p. 417-427
Kurzfassung:
The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired‐click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left‐hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left‐hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right‐hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.
Materialart:
Online-Ressource
ISSN:
0048-5772
,
1469-8986
DOI:
10.1111/psyp.2005.42.issue-4
DOI:
10.1111/j.1469-8986.2005.00299.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2005
ZDB Id:
1484299-3
SSG:
5,2
