In:
Alcoholism: Clinical and Experimental Research, Wiley, Vol. 20, No. s9 ( 1996-12)
Abstract:
In the present study, we evaluated the role of high‐density lipoprotein (HDL) as an endotoxin‐binding protein in chronically alcohol‐fed rats. Although the blood endotoxin level was significantly elevated in chronic ethanol‐loaded rats, compared with control rats, serum tumor necrosis factor (TNF), ALT, and lactate dehydrogenase were not elevated. Serum HDL and its endotoxin‐binding capacity were significantly increased in chronic ethanol‐loaded rats. When Kupffer cells isolated from control and chronic ethanol‐loaded rats were cultured in the medium containing 3 to 30 mg/dl HDL and endotoxin (500 ng/ml), endotoxin uptake and TNF production of Kupffer cells were decreased in proportion to the concentration of HDL in the medium. These results suggest that the increase in endetoxin‐binding capacity of HDL may serve as a protective mechanism against endotoxin in chronic ethanol‐loaded rats.
Type of Medium:
Online Resource
ISSN:
0145-6008
,
1530-0277
DOI:
10.1111/acer.1996.20.issue-s9
DOI:
10.1111/j.1530-0277.1996.tb01807.x
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
2046886-6
detail.hit.zdb_id:
3167872-5
SSG:
15,3
