In:
APMIS, Wiley, Vol. 120, No. 10 ( 2012-10), p. 828-835
Kurzfassung:
Syphilis is a sexually transmitted infection caused by the T reponema pallidum subspecies pallidum spirochete bacterium. The killer cell immunoglobulin‐like receptors ( KIR ), interacting with human leukocyte antigens ( HLA ), regulate the activations of natural killer ( NK ) cells and certain T ‐cell subsets in response to microbe infection. The objective of this study was to explore whether KIR and HLA ‐ C gene polymorphisms were associated with syphilis in a C hinese H an population. Polymerase chain reaction with sequence‐specific primers ( PCR ‐ SSP ) method was used to genotype KIR and HLA ‐ C genes in 231 syphilis patients and 247 healthy controls. Framework genes KIR2DL4 , KIR3DL2 , KIR3DL3 and KIR3DP1 were present in all individuals. The frequencies of KIR2DS3 and KIR3DS1 were higher in syphilis patients than in healthy controls (p = 0.030 and p = 0.038, respectively), while the frequency of KIR2DS5 was higher in healthy controls than in syphilis patients (p = 0.015; OR = 0.575). The homozygote for HLA ‐ C1 allele ( HLA ‐ C1C1 ) was more common in controls compared with syphilis patients (p = 0.030; OR = 0.667). The frequency of individuals with HLA ‐ C1C1 and KIR2DL3 genotype was higher in control group relative to syphilis patient group (p = 0.018; OR = 0.647). These data indicated that KIR2DS3 and KIR3DS1 were more prevalent in syphilis patients than in controls, and that KIR2DS5 , HLA ‐ C1C1 and HLA ‐ C1C1 ‐ KIR2DL3 were more prevalent in controls than in syphilis patients, respectively. These will require further investigation using functional studies.
Materialart:
Online-Ressource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2012.120.issue-10
DOI:
10.1111/j.1600-0463.2012.02911.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2012
ZDB Id:
2098213-6
SSG:
12
