In:
APMIS, Wiley, Vol. 120, No. 10 ( 2012-10), p. 846-854
Abstract:
The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico‐pathological parameters and prognosis of the disease. Using tissue arrays ( TA ), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours ( BOT ) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer ( OC ) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut‐off level for cyclin E overexpression, 20% of the BOT s were positive with a higher proportion of serous than mucinous tumours. Sixty‐two per cent of the OC s were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut‐off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to D anish OC patients.
Type of Medium:
Online Resource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2012.120.issue-10
DOI:
10.1111/j.1600-0463.2012.02913.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2098213-6
SSG:
12