In:
Journal of Medical Primatology, Wiley, Vol. 22, No. 4 ( 1993-06), p. 253-256
Abstract:
We attempted to define the etiology of anemia in SIV‐infected rhesus macaques. Bone marrow culture showed significantly decreased (75% reduction) burst forming unit‐erythroid (BFU‐E) growth in end‐stage SIV + “sick” animals. Direct antiglobulin tests (DAT) were positive in nine of 35 SIV + “well” and 14 of 14 SIV + “sick” monkeys (0 of 25 control animals had positive DATs). In animals with a positive DAT, moderate to severe anemia was observed, as was increased LDH and spherocytosis. Erythropoietin was measured in four control, eight SIV + “well” and five SIV + “sick” animals with mean levels of 4.0, 15.4, and 1176 mU/mL (r = .94) in the three groups. These data suggest that the cause of anemia in the SIV‐infected rhesus macaque is multifactorial, that there may be a defect in erythropoiesis, and that, serologically, an IgG mediated autoimmune hemolytic anemia is also present.
Type of Medium:
Online Resource
ISSN:
0047-2565
,
1600-0684
DOI:
10.1111/j.1600-0684.1993.tb00665.x
Language:
English
Publisher:
Wiley
Publication Date:
1993
detail.hit.zdb_id:
2026219-X