In:
Journal of Medical Primatology, Wiley, Vol. 27, No. 2-3 ( 1998-04-06), p. 129-140
Abstract:
Abstract: Isolated intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL) from jejunum of SIV infected animals were examined for alterations in basal cytokine expression by RT‐PCR. Remarkable changes in IFNγ and IL‐10 RNA levels were observed in IEL and LPL in SIV infection while IL‐4 and IL‐2 RNA levels remained unaltered. In addition, the CD4+ and CD8+ LPL were examined for intracellular cytokine production following mitogenic activation by flowcytometry. Both CD4+ and CD8+ T lymphocytes in intestinal mucosa retained the potential to produce IFNγ in response to mitogenic stimulation in vitro , without a remarkable change in IL‐4 production. The dominant IFNγ cytokine response could be one of the major contributing factors in SIV associated enteropathy.
Type of Medium:
Online Resource
ISSN:
0047-2565
,
1600-0684
DOI:
10.1111/jmp.1998.27.issue-2-3
DOI:
10.1111/j.1600-0684.1998.tb00237.x
Language:
English
Publisher:
Wiley
Publication Date:
1998
detail.hit.zdb_id:
2026219-X