In:
Chemical Biology & Drug Design, Wiley, Vol. 72, No. 3 ( 2008-09), p. 189-196
Abstract:
A series of 15 cinnamoyl triazole derivatives was prepared by Cu(I)‐catalyzed azide/alkyne [3+2]‐cycloaddition reactions and examined as inhibitors of guinea‐pig liver transglutaminase. Several compounds exhibited activity as reversible inhibitors that were competitive with acyl donor transglutaminase substrates. For example, triazole 4d has a K i value of 174 n m and represents one of the most potent reversible transglutaminase inhibitors reported to date.
Type of Medium:
Online Resource
ISSN:
1747-0277
,
1747-0285
DOI:
10.1111/jpp.2008.72.issue-3
DOI:
10.1111/j.1747-0285.2008.00696.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2216600-2
SSG:
12