In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1171, No. 1 ( 2009-08), p. 137-148
Kurzfassung:
Anthocyanins belong to a class of flavonoids exhibiting antioxidant and anti‐inflammatory actions as well as a variety of chemotherapeutic effects. However, little is known about the cellular and molecular mechanism of anticancer activity. In this study, we investigated if the anthocyanins (delphinidin‐3,5‐diglucoside: cyanidin‐3,5‐diglucoside: petunidin‐3,5‐diglucoside: delphinidin‐3‐glucoside: malvdin‐3,5‐diglucoside: peonidin‐3,5‐diglucoside: cyanidin‐3‐glucoside: petunidin‐3‐glucoside: peonidin‐3‐ glucoside: malvidin‐3‐ glucoside = 27: 63: 8.27: 1:2.21: 6.7: 1.25: 5.72: 1.25) isolated from meoru ( Vitis coignetiae Pulliat) exerted antiproliferative and anti‐invasive and apoptotic effects on human hepatoma Hep3B cells. It was found that the anthocyanins could inhibit cell growth by 75% at the concentration of 400 μg/mL for 48 h. Flow cytometric analysis showed that the anthocyanins increased the amount of DNA fragments (sub‐G1 fraction) in a dose‐dependent manner, which is closely related to mitochondrial dysfunction and reduction in antiapoptotic proteins (Bcl‐2, xIAP, cIAP‐1, and cIAP‐2). The anthocyanins also significantly inhibited the migration and invasion of Hep3B cells through a matrigel‐coated chamber. Taken together this study indicates that the anthocyanins from meoru have antiproliferative and anti‐invasive effects and may induce apoptosis through the activation of the mitochondrial pathway and inhibition of antiapoptotic proteins. This study provides evidence that the anthocyanins isolated from meoru might be useful in the treatment of human hepatitis B‐associated hepatoma.
Materialart:
Online-Ressource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2009.1171.issue-1
DOI:
10.1111/j.1749-6632.2009.04689.x
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2009
ZDB Id:
2834079-6
ZDB Id:
211003-9
ZDB Id:
2071584-5
SSG:
11
