In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 25, No. 2 ( 2021-01), p. 1001-1011
Abstract:
Cardiac fibrosis, featuring abnormally elevated extracellular matrix accumulation, decreases tissue compliance, impairs cardiac function and accelerates heart failure. Mounting evidence suggests that the ubiquitin proteasome pathway is involved in cardiac fibrosis. In the present study, ubiquitin‐specific protease 2 (USP2) was identified as a novel therapeutic target in cardiac fibrosis. Indeed, USP2 expression was increased in angiotensin II–induced primary cardiac fibroblasts (CFs) from neonatal rats. In addition, USP2 inhibition suppressed CFs proliferation, collagen synthesis and cell cycle progression. Furthermore, USP2 interacted with β‐catenin, thereby regulating its deubiquitination and stabilization in CFs. To sum up, these findings revealed that USP2 has a therapeutic potential for the treatment of cardiac fibrosis.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2076114-4
