In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 29, No. S4 ( 2014-12), p. 20-24
Kurzfassung:
Several studies have reported that the application of rebamipide during the eradication of H elicobacter pylori can improve the eradication rate. However, the efficacy and safety are controversial. The present study systematically evaluated whether rebamipide improves the eradication rate of H . pylori by conducting a meta‐analysis based on randomized controlled trials ( RCTs ). Methods Literature searches were conducted in the following database: P ub M ed, the C ochrane L ibrary, and the I gaku‐chuo‐zasshi database in J apan. A meta‐analysis of all RCTs comparing rebamipide supplementation with non‐rebamipide‐containing therapy was performed. Results We identified six randomized trials (611 patients). Pooled H . pylori eradication rates by per‐protocol analysis were 73.3% and 61.4% for patients with or without rebamipide, respectively. The odds ratio was 1.74 (95% confidence interval. 1.19–2.53). Conclusions Supplementation with rebamipide might be effective in increasing the H . pylori eradication rates of proton‐pump inhibitor–amoxicillin dual therapy.
Materialart:
Online-Ressource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2014.29.issue-s4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2006782-3
