In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 31, No. 7 ( 2016-07), p. 1280-1283
Abstract:
H 2 S is an important gasotransmitter in the gastrointestinal tract. The aim of the present study was to investigate the effect of exogenous H 2 S on gastric acid secretion. Methods Male Wistar rats were randomly divided into physiological saline (PS) group, sodium hydrosulfide (NaHS; 50, 100, and 150 µmol/kg body weight) group, glibenclamide + NaHS group, and SQ22536 + NaHS group. PH of gastric juice before injection and after injection were determined by a PH meter. Results The results showed that NaHS, an exogenous H 2 S donor, injected into the enterocoelia significantly reduced the PH of gastric juice, the same volume of PS administered similarly did not change PH of gastric juice, the promotional effect of NaHS on gastric acid secretion could be abolished by glibenclamide, an ATP‐sensitive potassium channel K(ATP) blocker SQ22536, an inhibitor of adenyl cyclase. Conclusions The data from these experiments suggest that exogenous H 2 S promoted gastric acid secretion, which may occur via K(ATP) channels and activate AC‐cAMP pathway.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2016.31.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2006782-3