In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 32, No. 6 ( 2017-06), p. 1230-1233
Abstract:
In registration studies, combination therapy of paritaprevir/ritonavir, ombitasvir, and dasabuvir (PrOD) with and without ribavirin for 12–24 weeks can achieve 〉 90% sustained virological response (SVR) for genotype 1 hepatitis C virus (HCV) infection. However, data in Asia is scanty. We aimed to study the efficacy and safety of this combination therapy in chronic hepatitis C patients in Hong Kong. Methods We retrospectively analyzed data from six local hospitals that have prescribed PrOD with and without ribavirin to patients with genotype 1 chronic HCV infection as part of a global compassionate program. Results Among 41 patients treated, 35 (85%) patients had genotype 1b HCV infection, 6 (15%) had co‐infection with human immunodeficiency virus, 35 (85%) failed previous peginterferon and ribavirin therapy, 25 (61%) had compensated liver cirrhosis, and 3 (7%) had liver transplantation. Thirty‐five (85%) patients received 12‐week treatment and six patients received 24‐week treatment; 26 (63%) patients received ribavirin combination. Thirty‐nine (95%; 95% confidence interval 88.5–100%) patients had undetectable HCV RNA at 12‐week post‐treatment, that is, SVR. The two patients who did not develop SVR discontinued treatment prematurely; both of them were treatment experienced with liver cirrhosis complicated by acute renal failure unrelated to the treatment of PrOD and ribavirin. No patient had hepatic decompensation. Conclusions Paritaprevir/ritonavir, ombitasvir, and dasabuvir with or without ribavirin is effective and safe in patients with genotype 1 HCV infection in real‐life clinical setting in Hong Kong.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2017.32.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2006782-3