In:
Journal of Medical Primatology, Wiley, Vol. 43, No. 6 ( 2014-12), p. 445-454
Abstract:
The objective of the current study was to determine changes to vascular parameters of nonhuman primate dominant ovarian structures by dynamic contrast‐enhanced ultrasound ( DCE ‐ US ). Materials and Methods Dynamic contrast‐enhanced ultrasound with intravenous microbubble infusion was performed on the rhesus macaque ovary bearing the pre‐ovulatory follicle and corpus luteum ( CL ) sequentially during the natural luteal phase (n = 8) and G n RH antagonist (antide)‐induced luteal regression (n = 6). Results Changes in luteal blood volume ( BV ) and vascular flow ( VF ) were observed between stages of the luteal phase Luteal BV was highest in early stage CL , before decreasing 2.5‐fold in late stage CL ( P 〈 0.06); in contrast, luteal VF peaked at mid luteal stage ( P 〈 0.01). Two females identified with luteal insufficiency trended toward lower peak BV , compared to typical CL s. Another female was identified with a luteal cyst on the contralateral ovary, and a CL that regressed before P levels declined. After 72 hours of antide exposure, BV was reduced 2.3‐fold ( P = 0.03). Conclusions DCE‐US provides a sensitive, non‐invasive measurement of the dynamics of blood volume and flow in dominant ovarian structures.
Type of Medium:
Online Resource
ISSN:
0047-2565
,
1600-0684
DOI:
10.1111/jmp.2014.43.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2026219-X