In:
Journal of Cosmetic Dermatology, Wiley, Vol. 15, No. 2 ( 2016-06), p. 162-168
Kurzfassung:
Chrysanthemum indicum , an oriental medicinal plant, has been shown to display a variety of pharmacological activities including antibacterial and anti‐inflammatory effects. Aims In this study, we evaluated the ability of C. indicum extracts to inhibit in vitro tyrosinase activity and the skin care effects of cosmetic formulations containing 0.5% C. indicum water extract in human volunteers. Patients/Methods The formation of dopachrome from L ‐ dopa by mushroom tyrosinase was observed after treatments with C. indicum extracts. The volunteers received placebo (no extract) or test (0.5% C. indicum water extract) cosmetic cream and applied it on their face three times a day for 6 weeks. Biophysical skin parameters were measured every 2 weeks. Results Chrysanthemum indicum methanol and water extracts dose dependently inhibited mushroom tyrosinase activity, and the effects of methanol extract were similar to those of kojic acid, a well‐known tyrosinase inhibitor. Clinical evaluations revealed that application of cosmetic formulations containing C. indicum water extract time dependently reduced melanin levels over 6 weeks, whereas the placebo group showed no effect. No changes in moisture, elasticity, wrinkles, evenness, and pore size were observed in either group. HPLC ‐ DAD ‐ ESIMS analyses revealed that luteolin and acacetin‐7‐ O ‐rutinoside are the major flavonoid compounds in C. indicum water extract. Conclusion These results suggest that C. indicum water extract could be applied as a natural skin‐whitening agent for functional cosmetic uses, due to its melanin‐reducing efficacy.
Materialart:
Online-Ressource
ISSN:
1473-2130
,
1473-2165
DOI:
10.1111/jocd.2016.15.issue-2
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2075528-4
