In:
Journal of Oral Pathology & Medicine, Wiley, Vol. 45, No. 6 ( 2016-07), p. 409-417
Abstract:
Oral cancer is the 4th leading cause of cancer death for males and the top cancer in young adult males in Taiwan. Tongue squamous cell carcinoma ( TSCC ) is a common oral cancer and generally associated with poor prognosis. Global DNA hypomethylation at the 5 position of cytosine (5mC) is a well‐known epigenetic feature of cancer. Therefore, the purpose of this study was to investigate the relationship of the global 5mC content with the tumorigenesis and prognosis of patients with TSCC . Methods The levels of global 5mC were evaluated by immunohistochemistry using tissue microarray slides of 248 surgically resected TSCC and 202 corresponding tumor adjacent normal ( TAN ) tissues. Results We found that the level of 5mC in TSCC ( P 〈 0.001) was significantly decreased as compared to TAN . Among TSCC tissues, decreased levels of 5mC were associated with female gender ( P = 0.036). In addition, the global hypomethylation was associated with the poor disease‐specific survival in TSCC patients (adjusted hazard ratio: 1.55, P = 0.043), especially for patients in older age group ( 〉 50 years, P = 0.013), with moderate or poor cell differentiation ( P = 0.044), early stage of disease (I‐ II , P = 0.046), small tumor size (T1–T2, P = 0.005), without lymph node involvement ( P = 0.041), and ever received postoperative radiotherapy ( P = 0.009). Conclusions Global hypomethylation was an independent biomarker for the development and poor prognosis of TSCC .
Type of Medium:
Online Resource
ISSN:
0904-2512
,
1600-0714
DOI:
10.1111/jop.2016.45.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2026385-5
