In:
Journal of Viral Hepatitis, Wiley, Vol. 26, No. S1 ( 2019-07), p. 90-97
Abstract:
We analysed the changes in viral protein expression in HBeAg‐negative chronic hepatitis B (CHB). In total, 160 samples were obtained from individuals infected by hepatitis B virus (HBV) and divided into four groups. Group A included 71 cases of hepatitis B e antigen (HBeAg)‐negative CHB, Group B included 58 cases of inactive seroconverters and Group C included 31 cases of HBeAg‐positive CHB. Group D included 22 normal healthy individuals as a control. All serum samples were examined using surface enhance laser desorption/ionization time of flight‐mass spectrometry (SELDI‐TOF‐MS). The results indicated that a peak with 4140 m/z increased markedly in Group A at 1295.55 ± 745.87, which was significantly different from that in Group B at 896.99 ± 534.86 ( P = 0.013). This peak indicated a close relationship with HBV DNA replication and may contribute to pathogenesis of HBeAg‐negative chronic hepatitis.
Type of Medium:
Online Resource
ISSN:
1352-0504
,
1365-2893
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2007924-2
