In:
Journal of Viral Hepatitis, Wiley, Vol. 28, No. 8 ( 2021-08), p. 1169-1176
Abstract:
Various non‐invasive methods have been evaluated in chronic hepatitis B, but none of them have been fully validated for the assessment of liver fibrosis. The issued EASL‐ALEH 2015 guidelines provide detailed algorithms based on LSM and ALT serum levels. The aim of our study was to validate the diagnostic accuracy of this algorithm and to better understand discrepancies. Four hundred and thirteen patients from 3 centres were retrospectively included. All included patients were classified for fibrosis stage according to results of a liver biopsy. The overall diagnostic value was expressed with AUROCs given with 95% confidence intervals for the diagnostic targets. For each diagnostic target, optimal cut‐offs were determined according to the Youden method. For the population of patients with ALT 〈 N ( n = 65), the AUROCs of TE were 0.75 (0.62–0.88) and 0.72 (0.56–0.88) for F ≥ 2 and F ≥ 3 diagnostic targets. Taking the EASL cut‐offs, the prevalence of significant fibrosis was 8%, 38% and 67% when LSM was 〈 6kPa, between 6 and 9 kPa or 〉 9 kPa, respectively. For patients with ALT 〉 N but ≤5N ( n = 306), AUROCs of transient elastography were 0.79 (0.73–0.84) and 0.84 (0.75–0.92) for F ≥ 2 and F ≥ 3 diagnostic targets. The prevalence of significant fibrosis was, respectively, 15%, 52% and 85% when LSM was 〈 6kPa, between 6 and 12 kPa or 〉 12 kPa. Our study independently validates the EASL‐ALEH algorithm based on ALT levels and LSM assessed by transient elastography.
Type of Medium:
Online Resource
ISSN:
1352-0504
,
1365-2893
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2007924-2
