In:
Liver International, Wiley, Vol. 35, No. 12 ( 2015-12), p. 2603-2610
Abstract:
To investigate the role of post‐operative intensity‐modulated radiotherapy ( IMRT ) in patients receiving narrow‐margin hepatectomy for hepatocellular carcinoma ( HCC ) located close to the major vessels. Methods This exploratory study involved 181 HCC patients. Of them, 116 were treated with narrow‐margin ( 〈 1.0 cm) hepatectomy. Thirty‐three of the 116 underwent postoperative IMRT (Group A), while 83 did not receive radiotherapy (Group B). The remaining 65 patients underwent wide‐margin (≥1.0 cm) hepatectomy (Group C). Prognosis and patterns of recurrence were assessed in the three groups. Results The 3‐year overall survival ( OS ) and disease‐free survival ( DFS ) rates were 89.1 and 64.2% in Group A, 67.7 and 52.2% in Group B and 86.0 and 60.1% in Group C respectively. The OS and DFS of Group A and Group C patients surpassed those of Group B patients (Group A vs. B, P = 0.009 and P = 0.038; and Group C vs. B, P = 0.002 and P = 0.010). Patients in Groups A and C experienced significantly fewer early recurrences than did patients in Group B ( P = 0.002). Furthermore, patients in Groups A and C experienced substantially fewer intrahepatic marginal ( P = 0.048) and diffuse recurrences ( P = 0.018) and extrahepatic metastases ( P = 0.038) than did patients in Group B. No patient developed radiation‐induced liver disease. Conclusions Post‐operative IMRT following narrow‐margin hepatectomy may be a favourable therapy for both its safety profile and clinical benefit in patients with HCC located close to the major vessels.
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
DOI:
10.1111/liv.2015.35.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2124684-1