In:
Microcirculation, Wiley, Vol. 25, No. 2 ( 2018-02)
Kurzfassung:
To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes in DO 2 and sublingual microcirculatory perfusion. Methods Fifteen healthy volunteers breathed increasing oxygen fractions for 10 minutes to reach arterial oxygen tensions of baseline (breathing air), 20, 40, 60 kPa, and max kP a (breathing oxygen). Systemic hemodynamics were measured continuously by the volume‐clamp method. At the end of each period, the sublingual microcirculation was assessed by SDF. Results Systemic DO 2 was unchanged throughout the study ( P slope = .8). PVD decreased in a sigmoidal fashion (max −15% while breathing oxygen, SD 18, P slope = .001). CI decreased linearly (max −10%, SD 10, P slope 〈 .001) due to a reduction in HR (max −10%, SD 7, P slope = .009). There were no changes in stroke volume or MAP. Most changes became apparent above an arterial oxygen tension of 20 kPa. Conclusions In healthy volunteers, supraphysiological arterial oxygen tensions have no effect on systemic DO 2 . Sublingual microcirculatory PVD decreased in a dose‐dependent fashion. All hemodynamic changes appear negligible up to an arterial oxygen tension of 20 kPa.
Materialart:
Online-Ressource
ISSN:
1073-9688
,
1549-8719
DOI:
10.1111/micc.2018.25.issue-2
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2008083-9