In:
Neuropathology, Wiley, Vol. 34, No. 2 ( 2014-04), p. 197-200
Abstract:
Teratomas are very rare intracranial tumors and cytogenetic information on this group remains rare. We report a case of a mature teratoma with abnormal +21 trisomy in tumor karyotype ocurring in a non‐Down syndrome ( DS ) infant. Additionally, the evidence for the contribution of chromosome 21 trisomy in this neoplasia are briefly reviewed. The 6‐month‐old male baby presented with a posterior fossa tumor. Histological evaluation of tumor specimen showed a mature teratoma composed of fully differentiated ectodermal, mesodermal and endodermal components. Although somatic karyotyping of the index case was normal, composite tumor karyotype depicted 47, XY , +21[6]/46, XY [6]. Besides previous reports of children with DS and intracranial teratomas, this is the first report to describe the occurrence of an isolated chromosome 21 trisomy within the tumor of a non‐ DS child. The participation of chromosome 21 in this rare pediatric tumor, either somatic or restricted to tumor specimen, may deserve special interest and further investigation.
Type of Medium:
Online Resource
ISSN:
0919-6544
,
1440-1789
DOI:
10.1111/neup.2014.34.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2008290-3