In:
Pigment Cell & Melanoma Research, Wiley, Vol. 27, No. 4 ( 2014-07), p. 565-579
Kurzfassung:
Little is known as to how cells ensure that organelle size and number are coordinated to correctly couple organelle biogenesis to the demands of proliferation or differentiation. OA 1 is a melanosome‐associated G ‐protein‐coupled receptor involved in melanosome biogenesis during melanocyte differentiation. Cells lacking OA 1 contain fewer, but larger, mature melanosomes. Here, we show that OA 1 loss of function reduces both the basal expression and the α‐melanocyte‐stimulating hormone/c AMP ‐dependent induction of the microphthalmia‐associated transcription factor ( MITF ), the master regulator of melanocyte differentiation. In turn, this leads to a significant reduction in expression of PMEL , a major melanosomal structural protein, but does not affect tyrosinase and melanin levels. In line with its pivotal role in sensing melanosome maturation, OA 1 expression rescues melanosome biogenesis, activates MITF expression and thereby coordinates melanosome size and number, providing a quality control mechanism for the organelle in which resides. Thus, resident sensor receptors can activate a transcriptional cascade to specifically promote organelle biogenesis.
Materialart:
Online-Ressource
ISSN:
1755-1471
,
1755-148X
DOI:
10.1111/pcmr.2014.27.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2425880-5
