In:
Pediatric Transplantation, Wiley, Vol. 19, No. 5 ( 2015-08), p. 563-570
Abstract:
The success of treating a wide variety of pediatric diseases with HSCT , hematologic malignancies in particular, has resulted in an increased number of long‐term survivors. This study is the first large‐scale, multicentre report that describes the evolution of pediatric HSCT s in C hina during the period of 1998–2012. Of all 1052 patients, 266 cases were treated with autologous HSC s and 786 used allogeneic HSC s. The disease indications for HSCT s mainly included leukemias, lymphoma, solid tumors, and non‐malignant disorders. The total number of HSCT s, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five‐yr OS and DFS rate of 34.5 ± 14.3% and 20.7 ± 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five‐yr OS and DFS rates were 82.8 ± 4% and 80.7 ± 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCT s in C hina over the past 14 yr.
Type of Medium:
Online Resource
ISSN:
1397-3142
,
1399-3046
DOI:
10.1111/petr.2015.19.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2008614-3